{blackbabes} Rashida Jones and Andy Samberg share a movie

In When Harry Met Sally, Billy Crystal famously proclaimed that men and women can't be friends.

New film Celeste and Jesse Forever argues that they can … once they get divorced.

Rashida Jones, 36, and Andy Samberg, 33, who star in the film, will get around to explaining that once they finish tormenting each other.

"Are you doing like a Madonna British accent thing?" Samberg interrupts Jones, in mid-character description of Celeste, a workaholic, judgmental media consultant.

Jones, recently back from London filming Cuban Fury, a film about salsa dancers, feigns insult: "What are you talking about? Did I sound British?"

Samberg: "Just sounded very pronounced and Madonna-esque." He moves onto describing Jesse, a 30-year-old artist who has failed to get it together over a decade-long marriage. "I play Jesse, titular character, so — "

Jones: "Don't say titular. Just don't."

The charming, bittersweet indie was written by Jones and writing partner Will McCormack, who dated briefly in the '90s. Inspired by Woody Allen and James Brooks films, Forever explores an "excruciatingly real" breakup.

Jones says the growing pains in Forever chronicle "that first step in adulthood that you're like, 'Wait a second, it doesn't always turn out the way my brain decides it's going to turn out,' " she says. "To me, that's the hardest part of getting older — realizing that things that feel good aren't always good for you and right for you in the long term."

Celeste (like Jones and Samberg in real life) has a penchant for being right. "Everybody plays by her rules or they don't exist in her world," Jones says.

"I think I'm a lot like Jesse in the way that I'm undeniably handsome. Like, model handsome," Samberg says with a grin.

Their characters attempt the impossible: They separate but stay in each other's lives (Jesse even lives in Celeste's guest house), keep their mutual friends and begin dating others. The plan, steered by Celeste, works until Jesse falls into a relationship cemented by an unplanned pregnancy.

The story line affected Samberg, who shows off dramatic chops in the film. "Time has passed, but I definitely feel more ready to have a child now than before we started shooting the movie," he says. "I was definitely forced into that head space and thought about what it would actually be like."

Jones and Samberg have been friends since they met at an after-party for the 2005 MTV Video Music Awards. Until recently, they shared a network: Jones will return to NBC's Parks and Recreation this fall; Samberg exited Saturday Night Live in May after seven years.

His post-SNL career launched with June's That's My Boy, which didn't impress at the box office. Samberg shrugs it off. "There's no way to know," he says. "It was a thrill to work with (Adam) Sandler. He's been my hero since I was a teenager."

Jones is working on a screenplay based on a comic book she wrote about a young socialite recruited to become a spy for the CIA.

"Can I make a quick side note about Archie comics?" Samberg cuts in. "Clearly Archie and Betty should be together, and Reggie and Veronica should be together."

Jones furrows her brow: "No, I don't think that's clear."

Samberg: "It's completely clear."

Jones adopts Celeste's tone: "If you just had one night, I think you'd go Veronica." Samberg: "I don't think so. I tend to go for the nice — "

"All right," Jones says, not buying it. "We'll agree to disagree."